MSK_profile

Thomas P. Kole, M.D., Ph.D.

Radiation Oncologist

I am an associate attending radiation oncologist at Memorial Sloan Kettering Cancer Center in Middletown, New Jersey. I earned my undergraduate degree from Johns Hopkins University where I also completed my doctoral studies in Chemical and Biomolecular Engineering. I subsequently completed a post-doctoral fellowship in Oncology at the Johns Hopkins School of Medicine before embarking upon my medical degree at Rutgers New Jersey Medical School in Newark, NJ. There, I was inducted into the Alpha Omega Alpha medical honor society and received the prestigious Stanley S. Bergen, Jr., M.D. Medal of Excellence. My post-graduate training includes a transitional year internship at Morristown Medical Center in Morristown, NJ, and residency in Radiation Oncology at Georgetown University Hospital in Washington, DC, where I also served as Chief Resident.

I am experienced in the treatment of genitourinary malignancies including prostate cancer, bladder cancer, testicular cancer, and kidney cancer. I have extensive training in the use of modern radiation therapy techniques including intensity modulated radiation therapy, stereotactic radiosurgery and stereotactic body radiotherapy. I also serve on the genitourinary malignancies section of the American Board of Radiology certifying exam committee for radiation oncology.

Education and Training

Education

BS, The Johns Hopkins University
Chemical Engineering
1995 – 1999

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PhD, The Johns Hopkins University
Chemical and Biomolecular Engineering
1999 – 2004

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Residency and Fellowship

Johns Hopkins Medical School
Oncology Research Fellow
2004 – 2006

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Atlantic Health System
Transitional Internship
2010 – 2011

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Georgetown University
Radiation Oncology
2011 – 2015

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Certifications and Awards

Certifications

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Awards

Whiting School of Engineering
Undergraduate Research Award
1999

NASA graduate fellowship
2001 – 2004

Alpha Omega Alpha
Medical Honor Society
2009

Stanley S. Bergen, Jr., M.D.
Medal of Excellence
2010

Atlantic Health
Resident Research Award
2011

Publications

Tseng, Y., T.P. Kole, S.H.J. Lee, and D. Wirtz. “Local dynamics and viscoelastic properties of cell biological systems”, Current Opinion in Colloid & Interface Science. 7(3-4):210-217, 2002 Pubmed

Tseng, Y.*, T.P. Kole*, and D. Wirtz. “Micromechanical mapping of live cells by multiple-particle-tracking microrheology”, Biophysical Journal. 83(6):3162-76, 2002 Pubmed

Xing, Y.C., T.P. Kole, and J.L. Katz. “Shape-controlled synthesis of iron oxide nanoparticles”, Journal of Materials Science Letters. 22(11):787-790, 2003 Pubmed

Kole, T.P.*, Y. Tseng, and D. Wirtz. “Intracellular microrheology as a tool for the measurement of the local mechanical properties of live cells”, Methods Cell Biol. 78:45-64, 2004 Pubmed

Tseng, Y., J.S. Lee, T.P. Kole, I. Jiang, and D. Wirtz. “Micro-Organization and Visco-elasticity of the Interphase Nucleus Revealed by Particle Nanotracking”, Journal of Cell Science. 117(10):2159-67, 2004 Pubmed

Kole, T.P., Y. Tseng, L. Huang, J.L. Katz, and D. Wirtz. “Rho kinase regulates the intracellular micromechanical response of adherent cells to rho activation”, Mol Biol Cell. 15(7):3475-84, 2004 Pubmed

Gundry, R.L., R. Edward, T.P. Kole, C. Sutton, and R.J. Cotter. “Disposable hydrophobic surface on MALDI targets for enhancing MS and MS/MS data of peptides”, Analytical Chemistry. 77(20):6609-17, 2005 Pubmed

Tseng, Y., T.P. Kole, J.S. Lee, E. Fedorov, S.C. Almo, B.W. Schafer, and D. Wirtz. “How actin crosslinking and bundling proteins cooperate to generate an enhanced cell mechanical response”, Biochem Biophys Res Commun. 334(1):183-92, 2005 Pubmed

Gupton, S.L., K.L. Anderson, T.P. Kole, R.S. Fischer, A. Ponti, S.E. Hitchcock-DeGregori, G. Danuser, V.M. Fowler, D. Wirtz, D. Hanein, and C.M. Waterman-Storer. “Cell migration without a lamellipodium: translation of actin dynamics into cell movement mediated by tropomyosin”, Journal of Cell Biology. 168(4):619-631, 2005 Pubmed

Kole, T.P., Y. Tseng, I. Jiang, J.L. Katz, and D. Wirtz. “Intracellular mechanics of migrating fibroblasts”, Mol Biol Cell. 16(1):328-38, 2005 Pubmed

Panorchan, P., J.S. Lee, T.P. Kole, Y. Tseng, and D. Wirtz. “Microrheology and ROCK signaling of human endothelial cells embedded in a 3D matrix”, Biophysical Journal. 91(9):3499-507, 2006 Pubmed

Lee, J.S., P. Panorchan, C.M. Hale, S.B. Khatau, T.P. Kole, Y. Tseng, and D. Wirtz. “Ballistic intracellular nanorheology reveals ROCK-hard cytoplasmic stiffening response to fluid flow”, Journal of Cell Science. 119(9):1760-8, 2006 Pubmed

Panorchan, P., J.S. Lee, B.R. Daniels, T.P. Kole, Y. Tseng, and D. Wirtz. “Probing cellular mechanical responses to stimuli using ballistic intracellular nanorheology”, Methods Cell Biol. 83:115-40. 2007 Pubmed

Zheng, Y., S.L. Collins, M.A. Lutz, A.N. Allen, T.P. Kole, P.E. Zarek, and J.D. Powell. “A role for mammalian target of rapamycin in regulating T cell activation versus anergy”, Journal of Immunology. 178(4):2163-70, 2007 Pubmed

Aggarwal, S., W.N. Brennen, T.P. Kole, E. Schneider, O. Topaloglu, M. Yates, R.J. Cotter, and S.R. Denmeade. “Fibroblast activation protein peptide substrates identified from human collagen I derived gelatin cleavage sites”, Biochemistry. 47(3):1076-86, 2008 Pubmed

Delgoffe, G.M., T.P. Kole, R.J. Cotter, and J.D. Powell. “Enhanced interaction between Hsp90 and raptor regulates mTOR signaling upon T cell activation”, Mol Immunol. 46(13):2694-8, 2009 Pubmed

Delgoffe, G.M., T.P Kole, Y. Zheng, P.E. Zarek, K.L. Matthews, B. Xiao, P.F. Worley, S.C. Kozma, and J.D. Powell. “The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment”,Immunity. 30(6):832-44, 2009 Pubmed

Kole, T.P., O. Aghayere, J. Kwah, E. Yorke, and K.A. Goodman. “A comparison of heart and coronary artery doses associated with intensity modulated radiotherapy (IMRT) versus 3-dimensional conformal radiotherapy (3DCRT) for distal esophageal cancer”, Int J Radiat Oncol Biol Phys., 2012 Pubmed

Linde, M.E., D.R. Colquhoun, C.U. Mohien, T.P. Kole, V. Aquino, R. Cotter, N. Edwards, J.E.K. Hildreth, and D.R. Graham. “The conserved set of host proteins incorporated into HIV-1 virions suggests a common egress pathway in multiple cell types”, Journal of Proteome Research. 12(5):2045-54, 2013 Pubmed

Wu, B., D. Pang, S. Lei, J. Gatti, M. Tong, T. McNutt, T.P. Kole, A. Dritschilo, and S.P. Collins. “Improved robotic stereotactic body radiation therapy plan quality and planning efficacy for organ-confined prostate cancer utilizing overlap-volume histogram-driven planning methodology”, Radiotherapy and Oncology. 112(2):221-6, 2014 Pubmed

Kole, T.P., R.C. Nichols, S. Lei, B. Wu, S.N. Huh, C. Morris, S. Lee, N. Mendenhall, A. Dritschilo, and S.P. Collins. “A dosimetric comparison of hypofractionated passively-scattered proton radiotherapy and stereotactic body radiotherapy (SBRT) in the definitive treatment of localized prostate cancer”, Acta Oncologica. Sep 17:1-7, 2014 Pubmed

Kole, T.P., L.N. Chen, O.O. Davies, J.S. Kim, S. Lei, S. Suy, A. Dritschilo, and S.P. Collins. “PSA kinetics following robotic Stereotactic Body Radiotherapy for localized prostate cancer”, Acta Oncologica. Dec 3:1-7, 2014 Pubmed

Kole, T.P., M. Tong, B. Wu, S. Lei, O.O. Davies , L.N. Chen, S. Suy, A. Dritschilo, E. Yorke, and S.P. Collins. “Late urinary toxicity modeling after stereotactic body radiotherapy (SBRT) in the definitive treatment of localized prostate cancer”, Acta Oncologica. May14:1-7, 2015 Pubmed

Janowski, E.M, T.P. Kole, L.N. Chen, J.S. Kim, T.M. Yung, B.T. Collins, S. Suy, J.H. Lynch, A. Dritschilo, and S.P. Collins. “Dysuria Following Stereotactic Body Radiation Therapy for Prostate Cancer”, Frontiers Rad. Onc. Jul3;5:151, 2015 Pubmed

Orloff, N.D., C.J. Long, J. Obrzut, L. Maillaud, F. Mirri, T.P. Kole, R.D. McMichael, M. Pasquali, S.J. Stranick, and J.A. Liddle. “Noncontact conductivity and dielectric measurement for high throughput roll-to-roll nanomanufacturing”, Nature Sci. Rep. Nov23;5:17019, 2015 Pubmed

Lischalk, J.W., T.P. Kole, H.M. Anjum, O.O. Davies, A. Rashid, and K. Unger. “Four-dimensional computed tomography prediction of inter- and intrafractional upper gastrointestinal tumor motion during fractionated stereotactic body radiation therapy”, Pract. Radiat. Oncol. May-Jun;6(3):176-82, 2016 Pubmed

Davies, O.O., T.P. Kole, B. Oppong, S. Rudra, E.V. Makariou, L.D. Campbell, H.M. Anjum, S.P. Collins, K. Unger, S. Willey, E. Tousimis, and B.T. Collins. “Stereotactic Accelerated Partial Breast Irradiation for early-stage breast cancer: rationale, feasibility, and early experience using the CyberKnife radiosurgery delivery platform”, Front. Oncol. May23;6:129, 2016 Pubmed

Paydar, I., A. Pepin, R.A. Cyr, J. King, T.M. Yung, E.G. Bullock, S. Lei, A. Satinsky, K.W. Harter, S. Suy, A. Dritschilo, J.H. Lynch, T.P. Kole, S.P. Collins. “Intensity-Modulated Radiation Therapy with Stereotactic Body Radiation Therapy Boost for Unfavorable Prostate Cancer: A Report on 3-Year Toxicity”,  Front. Oncol. Feb7;7:5, 2017 Pubmed

Repka M.C., T.P. Kole, J. Lee, B. Wu, S. Lei, T. Yung, B.T. Collins, S. Suy, A. Dritschilo, J.H. Lynch, S.P. Collins. “Predictors of acute urinary symptom flare following stereotactic body radiation therapy (SBRT) in the definitive treatment of localized prostate cancer”, Acta Oncologica. Aug;56(8):1136-1138, 2017 Pubmed

Lischalk J.W., H. Chen, M.C. Repka, L.D. Campbell, O. Obayomi-Davies, S. Kataria, T.P. Kole, S. Rudra, B.T. Collins. “Definitive hypofractionated radiation therapy for early stage breast cancer: Dosimetric feasibility of stereotactic ablative radiotherapy and proton beam therapy for intact breast tumors”, Adv Radiat Oncol. Jun 11;3(3):447-457. 2018 Pubmed

Repka M.C., M. Carrasquilla, I. Paydar, B. Wu, S. Lei, S. Suy, S.P. Collins, T.P. Kole. “Dosimetric predictors of acute bowel toxicity after Stereotactic Body Radiotherapy (SBRT) in the definitive treatment of localized prostate cancer”, Acta Oncol. Feb 24:1-6., 2023 Pubmed

Worth M., D.C. Brancato, J. Lo, T.P. Kole. “Impact of intrafraction fiducial tracking on planning target margins during prostate stereotactic body radiotherapy using Brainlab ExacTrac Dynamic with robotic couch correction” J Appl Clin Med Phys. Dec;26(12). 2025 Pubmed